History of HHT

W. Osler

Sir William Osler M.D. (1849-1919) was a Canadian physician, the first Professor of Medicine at Johns Hopkins, and one of the founders of Johns Hopkins Hospital. He differentiated HHT from haemophilia because the patients did not bleed profusely from lacerations, an important distinction that identifies HHT as a single entity (not part of haemophilia). Osler described two new familial cases of HHT, initially establishing that this disorder is passed down through generations.

F.P. Weber

Dr. Frederick Parkes Weber, M.D. (1863 – 1962), followed in his father’s footsteps, earning his medical degree at Cambridge in 1892. In 1907, he amplified the clinical description in a report of a series of cases. At the beginning of the 20th century Osler’s name was appended to the disorder, but the triple names came into use and has now gained universal acceptance.

H.J.L Rendu

Henri Jules Louis Marie Rendu (1844-1902) was a French physician. Rendu observed the skin and mucosal lesions and in 1896 distinguished HHT as a disorder separate from haemophilia.

The term hereditary haemorrhagic telangiectasia (HHT) was first used by the American physician Frederic M. Hanes in 1909 in an article on the condition.

However, even nowadays, many physicians still refer to the disorder by the three names.